Platform
NetMAPPR integrates computation, biology and chemistry to search expansively, validate rigorously, and prioritize for clinical and commercial potential
NetMAPPR Platform Discovery and Validation
Tightly Integrated and Iterative Computational and Experimental Platforms
Mechanistic
Rationale
- Network biology establishing causal link between biomarker and target
- Understanding of sensitizing and resistance factors
Penetrance
- Confirmed in multiple cancer types
- Confirmed in multiple cell lines (genetic backgrounds)
In Vitro Pharmacology
- More sensitivity to pharmacological agent in presence of biomarker
- Isogenic cell lines
- Cell line / PDX panels
In Vivo Pharmacology
- Anti-tumor efficacy in biomarker mutant settings
- Isogenic cell line xenografts
- PDX models
Biomarker and Clinical Relevance
- Prevalence of biomarker mutation
- Link to worse prognosis
- Biomarker on approved diagnostic panel
Target and Drug Development
- Druggable for new drug discovery campaign
- Existing drug candidates available