Scientist I/II

The candidate will work closely with our senior management and lead scientists in the area of drug target discovery, with focus in oncology and immuno-oncology.  They will plan and execute critical experiments, including in partnership with service companies and pharma partners. The successful candidate will bring cutting-edge, hands-on industry or equivalent academic expertise in immuno-oncology, including use of T cells and other human immune cell populations. The candidate will have demonstrated experience leading cross-functional projects with external collaborators.

• Hands-on molecular and cell biology in support of genetic screening, experimental design, resource planning, execution, and data analysis.

• Characterization of new targets and work with bioinformaticians to investigate gene networks involved in immune cell functioning.

• Design studies to validate novel targets using in vitro CRISPR-Cas screens in mammalian cells.

• Bring capability of transcriptomics efforts- establishing both bulk and single cell RNA-seq technologies and data analysis platform.

• Work collaboratively with the Engine teams in Asia and US.

• Involved in collaborations with external partners, including academic labs.

• Writing scientific work plans and project proposals and managing budgets, timelines, communications, and priorities.

• Contribute to scientific strategy and planning as necessary.

The above listed responsibilities are essential duties associated with this position; however, they are not an exhaustive list. Changes to individual responsibilities may occur due to business needs.

• Ph.D. with 3+ years of relevant work experience in cell biology / molecular biology / genomics. In depth understanding of immune-oncology.

• Proven track record in planning and execution of genomic screens, e.g. CRISPR-Cas, RNAi, and use of functional genomics data for therapeutic target identification.

• Strong experimental molecular and cell biology techniques, such as mammalian tissue culture.

• Preferred experience in developing successful collaborations and relationships with academic and/or industrial partners and KoLs.

• Excellence and rigor in data interpretation skills, demonstrated by a successful track record in overseeing projects.

• Cross-functional team experience, including experience working with global teams is a plus.

• Excellent interpersonal communication skills – verbal, written, and presentations.

• Experience mentoring junior scientists and research associates.

• 1-3 years of pharma R&D experience is preferred.

• Strong peer-reviewed publication record

In addition to above, the candidate will be expected to have:

• Ability to work in a multi-disciplinary team across time-zones.

• Ability to prioritize responsibilities and multi-task effectively.

• Excellent documentation and organization skills.

• Ability to maintain confidentiality and security of project information.

• Self-motivated, willing to learn, and able to work independently on projects.

• Willingness to mentor junior scientists and research associates.

To apply, please e-mail your CV to biology.jobs.sg@enginebio.com